Beijing, November 26th-28th, 2009



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Past Conferences
> BioCAS 2007

> BioCAS 2008





Tutorial 1



9:35 AM -10:35 AM, Nov. 26th, 2009.





Prof. Zhihua Wang

Tsinghua University


Title: Research and development activities in bio-medical circuits and systems in China



The research and development activities in the field of medical electronics and integrated circuits in China were reviewed. Case study at Institute of Microelectronics of Tsinghua University was given in this presentation. Research supporting programs in China were introduced first. The criteria to support the selection of research topic are present. The requirements for the integrated circuits used for the medical application are addressed. A few carrying on projects used for in medical application are presented. The projects include the IC design for the smart capsule, retina implants, cochlear implants and hear aids.


Speaker Bio:

Zhihua Wang (M'99-SM'04) received the B.S., M.S., and Ph.D. degree in electronic engineering from Tsinghua University, Beijing, China, in 1983, 1985, and 1990, respectively. In 1983, he became a faculty member of Tsinghua University, where he has been a full Professor since 1997 and Deputy Director of Institute of Microelectronics since 2000. From 1992 to 1993, he was a visiting scholar at Carnegie Mellon University, USA. From 1993 to 1994, he was a visiting researcher at K.U. Leuven, Belgium. His current research mainly focuses on CMOS RFIC and biomedical applications. His ongoing projects include RFID, PLL, low power wireless transceivers, and smart clinic equipment with combination of leading edge CMOS RFIC and digital imaging processing techniques. He has published over 180 papers and 3 books, and he holds 25 patents, with over 10 pending.


Prof. Wang is one of the chief scientists of China Ministry of Science and Technology, and serves on the expert committee of the National High Technology Research and Development Program of China (863 Program) in the area of information science and technologies. He was the founding chair of IEEE Solid-State Circuit Society Beijing Chapter since 1999. He has been a TPC member of IEEE International Solid-State Circuit Conference (ISSCC) since 2005. He currently serves as an associate editor for IEEE Transactions on Biomedical Circuits and Systems.


Tutorial 2



11:00 AM -12:30 PM, Nov. 26th, 2009.





Prof. Ralph Etienne-Cummings

Johns Hopkins University



Dr. John V. Arthur

Stanford University







Title: High Resolution Stimulations and Recording of The Peripheral and Central Nervous System for Sensory Feedback in Prosthetic Limbs



As prosthetic limbs that are neurally integrated into the nervous system are developed, it becomes necessary to invent new ways to record activity from, and to communicate sensory data to the nervous system.  This is particularly true for upper limb prosthetic devices, where the location of recording activity and communicating sensory data happens in the cortex.  Hence, this talk will summarize some of the work that has been done to develop implantable neural recording and stimulation devices.  It will conclude with some brand new sensory feedback experimental results.


Speaker Bio:

Ralph Etienne-Cummings received his B. Sc. in physics, 1988, from Lincoln University, Pennsylvania. He completed his M.S.E.E. and Ph.D. in electrical engineering at the University of Pennsylvania in December 1991 and 1994, respectively. Currently, Dr. Etienne-Cummings is a professor of electrical and computer engineering, and computer science at Johns Hopkins University (JHU). He is the former Director of Computer Engineering at JHU and the Institute of Neuromorphic Engineering (currently administered by University of Maryland, College Park). He is also the Associate Director for Education and Outreach of the National Science Foundation (NSF) sponsored Engineering Research Centers on Computer Integrated Surgical Systems and Technology at JHU. He has served as Chairman of the IEEE Circuits and Systems (CAS) Technical Committee on Sensory Systems and on Neural Systems and Application, and was re-elected as a member of CAS Board of Governors from 1/2007 - 1/2009. He was also the General Chair of the IEEE BioCAS 2008 Conference. He was also a member of Imagers, MEMS, Medical and Displays Technical Committee of the ISSCC Conference from 1999 - 2006. He is the recipient of the NSF's Career and Office of Naval Research Young Investigator Program Awards. In 2006, he was named a Visiting African Fellow and a Fulbright Fellowship Grantee for his sabbatical at University of Cape Town, South Africa. He was invited to be a lecturer at the National Academies of Science Kavli Frontiers Program, held in November 2007. He has also won publication awards, including the 2003 Best Paper Award of the EURASIP Journal of Applied Signal Processing and ''Best Ph.D. in a Nutshell'' at the IEEE BioCAS 2008 Conference, and has been recognized for his activities in promoting the participation of women and minorities in science, technology, engineering and mathematic. His research interest includes mixed signal VLSI systems, computational sensors, computer vision, neuromorphic engineering, smart structures, mobile robotics, legged locomotion and neuroprosthetic devices.


John V. Arthur is a Research Associate in the Brains in Silicon Lab at Stanford University. He received the B.S.E. degree (summa cum laude) in electrical engineering from Arizona State University and the Ph.D. degree in bioengineering from the University of Pennsylvania in 2000 and 2006, respectively. In his nine years in neuromorphic engineering, John has designed a number of silicon neurons, including the first spiking log-domain neuron. Currently, he is the lead analog/neuron designer for the Neurogrid project, which aims to build a desktop supercomputer for neuroscientists, allowing them to model complex cortical systems of up to 1 million neurons at a fraction of the cost of a general purpose supercomputer. His research interests include mixed-mode very large-scale integration, neuromorphic learning systems, silicon olfactory recognition, generation of neural rhythms, and asynchronous interchip communication.


Tutorial 3



14:00 PM -15:30 PM, Nov. 26th, 2009.





Dr. Nikolov Svetoslev

BK Medical


Title: Synthetic aperture ultrasound imaging and its real-time implementation



Synthetic aperture ultrasound imaging (SAUI) offers many advantages compared to traditional ultrasound imaging. SAUI can attain a higher frame rate, better resolution and contrast and it possible to perform quantitative vector flow imaging. The tutorial will explain about problems and solutions for making SA imaging with a good penetration depth and high quality. I will also be shown that the theoretical advantages translate into the clinic, and it will be described how to make flow imaging. The Achilles heal of SAUI is the large amount of calculations to be performed in such a system, and this currently precludes the introduction of commercial systems. A step to solving this is the experimental Synthetic Aperture Real-time Ultrasound System (SARUS) developed a Center for fast Ultrasound Imaging. It can perform real time SA imaging and storage of RF channel data for multiple seconds. The design principles of the scanner will be described. SARUS sample and process 1024 channel simultaneously giving data rates of 140 Gbytes/s. Using 320 large FPGAs the full system can perform 25,600 billion multiplications/s. The design of the parametric beamformer will be described as well as the principles for controlling such a large system through a simple Matlab interface. The system is capable of real time synthetic aperture imaging.


Speaker Bio:

Svetoslav I. Nikolov received a M.Sc. in electrical engineering and a M.B.A in international business relations from the Technical University - Sofia in 1996 and 1997, respectively. In 2001 he got a Ph.D. degree from the Technical University of Denmark, Lyngby. His dissertation explored approaches for synthetic aperture tissue and flow imaging, and possibilities to apply it to real-time 3D imaging. He did some of the first in-vivo synthetic aperture scans, developed a method for generating a new image at every transmission, and invented a method to estimate flow using synthetic aperture acquisitions. During the time he participated in the development of an experimental system for real-time acquisition of data for synthetic aperture imaging and wrote the system software.

After completing his doctoral work, he stayed on at the Technical University of Denmark first as an Assistant and later as an Associate Professor, where he taught digital design, software development, and digital signal processing. In 2008 Svetoslav Nikolov joined BK Medical as a system engineer in the R&D department where he works on the development of new imaging algorithms. Presently he is involved in a research project in collaboration with the Center for Fast Ultrasound Imaging, Technical University of Denmark, working on the development of an experimental system for real-time synthetic aperture imaging (SARUS). Svetoslav Nikolov is an author of over 40 scientific papers and two patents.


Tutorial 4



15:45 PM -17:15 PM, Nov. 26th, 2009.





Prof. Sandro Carrara

Swiss Federal Institute of Technology - Lausanne (EPFL)


Title: CMOS-circuits/samples interface: improvements by nanotechnology in label-free diagnostics



Personalized therapy requires accurate and frequent monitoring of the metabolic response by treated patients. In case of high risk side effects, e.g. therapies with interfering anti-cancer molecule cocktails, direct monitoring of the patient's drugs metabolism is essential as the metabolic pathways efficacy is highly variable on a patient-by-patient basis. Currently, there are no fully mature point-of-care bio-sensing systems for drugs metabolism monitoring directly in blood. To develop low-cost Point-of-care technology, the development of dedicated IC circuits is highly required. On the same time, there are not technologies for on-line monitoring in real-time of stem cell cultures. Many details of stem cells biology are still missing and new platform for non-invasive monitoring in real-time during cells proliferation, switching and differentiation are definitely required. The aim of the present talk is to show possible directions to develop systems for real-time monitoring to be used in personalized therapy or in regenerative medicine. Enzymes are the considered probe molecules as they are key proteins directly involved in cells metabolism. Sensitivity improvement is ensured by means of enzyme integration onto electrodes structured by using carbon nanotubes. The physics of this improvement is investigated meanwhile recent data on metabolites monitoring are presented. Finally, a VLSI design perspective is traced toward new biochip architectures for personalized therapy or regenerative medicine. Different CMOS designs are compared toward IC biochip developments especially focused to distributed sensors and their integration in sensor networks.


Speaker Bio:

Sandro Carrara graduate in Electronics in Technical school of Albenga, got a Master in Physics from Genoa University and received his Ph.D. in Biochemistry and Biophysics from Padoa University. His main scientific interest is on electrical phenomena mediated by nano-structured and molecular thin films. He currently has a special focus on development of protein and DNA based CMOS chips. He has more then 60 international publications and 10 patents. In 1996, he won a NATO Advanced Research prize for his original contribution on the role of nano-particles size in single-electron conductivity. From 1997 to 2000, he was a member of an international committee at the ELETTRA Synchrotron. From 2000 to 2003, he was scientific leader of a National Research Program (PNR) in the filed of Nanobiotechnology. In 2006, he received the best 2006 referees' award from Biosensor and Bioelectronics journal. He is Associate Editor of the IEEE Transactions on Biomedical Circuits and Systems, and referee of other eleven international journals. He is an internationally esteemed expert of the evaluation panel of the Academy of Finland in a research program for the years 2010-2013. He is the Publication Chair and a member of the Tutorial Chairs Board of the IEEE international conference on Biomedical Circuits and Systems, (Beijing, November, 2009). He also is the Chair of a Workshop on Nano-Bio-Sensing paradigms and applications (Luzern, October, 2009). He has been Professor in Biophysics at Genoa University and in Nanobiotechnology at Bologna University. He recently joined the EPFL - Swiss Federal Institute of Technology in Lausanne - where he is Senior Research Scientist.